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Associate Professor Jennifer L Martin
Institute for Molecular Bioscience
University of Queensland
Brisbane, Qld 4072
Email: j.martin@imb.uq.edu.au
Tel: +61-7-3346-2016
Fax: +61-7-3346-2101
Homepage: http://www.imb.uq.edu.au/index.html?id=11702
| Research |
| We use structural biology to investigate the interaction between protease inhibitors and proteases and this also provides a starting point for structure-based inhibitor design. We have worked on several different proteases including viral proteases such as HIV protease (collaboration with David Fairlie and Paul Alewood) and the NS3 proteases of Dengue and West Nile viruses (collaboration withy Paul Young and David Fairlie). We are currently working on the structure of the only known mammalian carboxypeptidase inhibitor, latexin, which is expressed in large amounts in inflammatory tissue (collaboration with David Hume and Bostjan Kobe). |
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| Collaborations |
Professor David Fairlie, IMB, UQ
Professor Paul Alewood, IMB UQ
Professor David Hume, IMB UQ
Associate Professor Bostjan Kobe, Biochemistry, UQ
Associate Professor Paul Young, Microbiology, UQ
Dr Rebecca Lew, Baker Institute
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| Publications |
Martin JL, Begun J, Schindeler A, Wickramasinghe WA, Alewood D, Alewood PF, Bergman DA, Brinkworth RI, Abbenante G, March DR, Reid RC and Fairlie DP (1999) ?Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease? Biochemistry 38, 7978-7988
Tyndall JDA, Reid RC, Tyssen DP, Jardine DK, Todd B, Passmore M, March DR, Pattenden LK, Bergman DA, Alewood D, Hu S-H, Alewood PF, Birch CJ, Martin JL, Fairlie DP (2000) "Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease" J Med Chem 43, 3495-3504
Leung, D.; Schroder, K.; White, H.; Fang, N.-X.; Stoermer, M. J.; Abbenante, G.; Martin, J. L.; Young, P.; Fairlie, D. P. "Activity Of Recombinant Dengue 2 Virus NS3 Protease In The Presence Of NS2B Cofactor, Small Peptide Substrates, And Inhibitors",J. Biol. Chem. 2001, 276, 45762-45771.
Arakaki TL, Fang N-X, Fairlie DP, Young PR and Martin JL (2002) ?Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography? Prot Expr Purif 25, 241-247
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