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Associate Professor Mark J Smyth
Cancer Immunology Program
Peter MacCallum Cancer Centre
St Andrew's Place, East Melbourne, Vic 3002
Email: mark.smyth@petermac.org
Tel:
Fax:
Homepage:
| Research |
| I am considered a world expert and have had an active interest in the lymphocyte granule exocytosis pathway of cell death for over 13 years. My initial involvement was to clone novel granzymes and aid in the elucidation of the biological activities of perforin and granzymes. In 1995 I became particularly interested in the biological significance of the granule exocytosis pathway in tumour control. I provided the first evidence that CTL do detect and kill pre-maligant cells via perforin thus vindicating Burnet and Thomas. 40 year hypothesis of tumour immunosurveillance. Over the last 8 years my studies on granzymes have focussed on three major projects involving additional collaborators: (1) Cloning and characterizing novel granzymes in collaboration with Dr. Thomas Sayers (NCI, Frederick, MD, USA) and Professor Dorothy Hudig (University of Nevada, NV, USA); (2) Determining the expression, protease activity, and function of granzyme M that I first isolated and cloned in 1992; and (3) My current work on granzymes is focussed on the important role of granzymes in response to some virus infections in collaboration with leading national authorities including Dr. Arno Mullbacher (John Curtain School of Medical Research, Canberra, Australia) (pox viruses) and Dr. Mariapia Degli-Esposti (MCMV). |
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| Collaborations |
Dr. Thomas Sayers (NCI, Frederick, MD, USA)
Professor Dorothy Hudig (University of Nevada, NV, USA)
Dr. Arno Mullbacher (John Curtain School of Medical Research, Canberra, Australia)
Dr. Mariapia Degli-Esposti (MCMV) |
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