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Dr Guiying Nie
Prince Henry's Institute of Medical Research
Monash University
Melbourne, Vic 3168
Email: guiying.nie@phimr.monash.edu.au
Tel: +61-3-9594-4380
Fax: +61-3-9594-6125
Homepage: http://www.med.monash.edu.au/non-cms/phimr/
| Research |
| My research focuses on the mechanisms of embryo implantation and placentation (development of a functional placenta), in particular, the influence exerted by the uterus. The endometrium or lining of the uterus is hostile to the implantation of an embryo except during a few days in each menstrual cycle. Using state-of-the-art technology, we have identified a number of molecules that are highly regulated at the time of uterine receptivity, embryo implantation and placentation. These molecules include a number of proteases such the proprotein convertase family and the HtrA family proteases. In particular, we identified and cloned the third member of the HtrA family, HtrA3. We are interested in both understanding the functions of these proteases at the molecular level and exploring the potentials of these molecules to be targets for treating infertility and for the development of post-coital contraception. |
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| Collaborations |
Department of Obstetrics and Gynaecology and Dept of Biochemistry, Monash University, Melbourne, Australia
Dr Martin Stafford-Bell, Canberra, Australia
Dr Steve Kridel, Wake Forest University School of Medicine, NC, USA
Shanghai Institute of Planned Parenthood Research, China
Chinese Academy of Sciences, Institute of Zoology, China
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| Publications |
L.A. Salamonsen and G.Y. Nie (2002) Proteases at the endometrial-trophoblast interface: their role in implantation. Reviews in Endocrine and Metabolic Disorders, 3, 135-145.
Nie GY, Li Y, Minoura H, Findlay JK, Salamonsen LA (2003) Specific and transient up-regulation of proprotein convertase 6 (PC6) at the site of embryo implantation and identification of a uterine-specific transcript in mouse uterus during early pregnancy. Biology of Reproduction 68, 439-447.
Nie GY, Hampton A, Li Y, Findlay JK, Salamonsen LA (2003) Identification and cloning of two isoforms of human HtrA3, characterisation of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. Biochemical J, 371, 39-48.
Nie GY, Li Y, Minoura H, Batten L, Ooi GT, Findlay JK, Salamonsen LA (2003) A novel serine protease of the mammalian HtrA family is dramatically up-regulated in mouse uterus coinciding with placentation. Molecular Human Reprod 9, 279-290.
Salamonsen LA, Dimitriadis E, Jones R, and Nie GY(2003) Complex regulation of decidualization: a role for cytokines and proteases. Placenta 24. Supplement A, Trophoblast Research, vol 17, S75-85, 279-290.
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