International Protease Network

Institute of Health and Biomedical Innovation
Queensland of University
Kelvin Grove, Qld 4059, Australia
Email: jd.hooper@qut.edu.au
Tel: +61-7-3138-6197
Fax: +61-7-3138-6030
Homepage:

Research

We are interested in understanding how serine proteases contribute to physiological and pathological processes. Broadly, our research themes extend across secreted serine proteases, such as the kallikrein-related peptidases, membrane associated enzymes, the type II transmembrane serine proteases, and, most recently, the cell surface substrates required for transduction of serine protease initiated signaling; including Protease Activated Receptors and other cell surface proteins.

Collaborations

Prof James Quigley, Scripps, USA
Prof Eleanor Mackie, University of Melbourne, Australia
Prof Qingyu Wu, Cleveland Clinic, USA
A/Prof Nathan Subramaniam, Queensland Institute of Medical Research, Australia
Prof David Fairlie, University of Queensland, Australia

Publications

Hooper JD, Nicol DL, Dickinson JL, Eyre HJ, Scarman AL, Normyle JF, Stuttgen MA, Douglas ML, Lakoski Loveland KA, Sutherland GR. and Antalis TM (1999) Testisin a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. Cancer Res. 59, 3199-3205.

Hooper JD, Scarman AL, Clark BE, Normyle JF and Antalis TM (2000) Localisation of the mosaic transmembrane serine protease corin to heart myocytes. Eur. J. Biochem. 267, 6931-6937.

Hooper JD, Clements JA, Quigley JP and Antalis TM (2001) Type II Transmembrane Serine Proteases - Insights into an Emerging Class of Cell Surface Proteolytic Enzymes. J. Biol. Chem. 276, 857-860.

Hooper JD, Bui LT, Rae FK, Harvey TJ, Ashworth LK and Clements JA (2001) Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed by prostate and skeletal muscle. Genomics 73, 117-122.

Hooper JD, Campagnola L, Goodarzi G, Truong TN, Stuhlmann H and Quigley JP. (2003) Mouse matriptase-2, identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues. Biochem. J. 373, 689-702.

Ramsay AJ, Reid JC, Velasco G, Quigley JP and Hooper JD (2008) The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles. Front. Biosci. 13, 569-79.

Ramsay AJ, Dong Y, Hunt ML, Linn M, Samaratunga H, Clements JA and Hooper JD (2008) Kallikrein-related peptidase (KLK) 4 initiates intracellular signalling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression. J. Biol. Chem. 283, 12293-12304.